Industries where occupational exposure to benzoapyrene has been measured and reported. Most of the pahs with low vapour pressure in the air are adsorbed on particles. Benzoapyrene bap is one of a large number of polycyclic aromatic hydrocarbons pahs that are formed during the incomplete combustion of organic matter. There are few studies addressing the molecular and.
Benzoapyrene, or bap, is one of a group of compounds called polycyclic aromatic hydrocarbons pahs. Benzo apyrene bap is the most potent carcinogenic substance among the pahs and as long as its relative contribution to total pah is relatively constant in foods, bap concentration is a good indicator of the total carcinogenic potency of a mixture alexander et al. Calculators benzoapyrene equivalents calculator multiple samples about dep. Section ii provides information on three aspects of the carcinogenic assessment for the substance in question. Benzoapyrene chemical agents and related occupations. Product name benzo apyrene product number fb18224 synonyms. More benzoapyrene bap is a polycyclic aromatic hydrocarbon and a potent inducer of carcinogenesis. Jrcirmm catalogue pdf format or jrcirmm catalogue search engine. Determination of benzoapyrene levels in smoked and oil.
Formation and persistence of benzoapyrene metabolitedna. Gcmsms analysis of benzoapyrene with agilent 7890 and 240. Pyrene is an ortho and perifused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system. More benzo apyrene bap is an environmental contaminant produced during incomplete combustion of organic material that is well known as a mutagenic and carcinogenic toxin. Bap is a polycyclic aromatic hydrocarbon and a component of air pollution. Less benzo apyrene bap is an environmental contaminant produced during incomplete combustion of organic. Manmade releases of benzoapyrene are to the air, where. The absorption of benzo apyrene from the gastrointestinal tract of mice and cats is enhanced when it is solubilized in vehicles possessing both lipophilic and hydrophilic properties ekwall et al. Recently, an increasing number of human and animal studies have reported that exposure to benzoapyrene bap induces neurological abnormalities and is also associated with adverse effects, such as tumor formation, immunosuppression, teratogenicity, and hormonal disorders. Many studies have reported that the carcinogenic effects of bap might be due to its intermediate metabolites and to reactive. Where can benzo apyrene be found and how is it used. Benzo a pyrene equivalents conversion table for multiple. Benzo apyrene levels in food food concentration ngg meat fried or broiled beef 0.
Evidence pertaining to the male reproductive toxicity of benzoapyrene in adult animals after oral or inhalation. The ubiquitous compound can be found in coal tar, tobacco smoke and many foods, especially grilled meats. Benzo a pyrene equivalents conversion table for multiple samples home divisions division of waste management petroleum restoration program benzo a pyrene equivalents conversion table for multiple samples. Expl ther a 1% soln of benzoapyrene in benzene was applied daily to protected and unprotected surfaces of skin of 26 patients suffering from pemphigus vulgaris, mycosis fungoides, prokeratosis, xeroderma pigmentosum, basal cell cancer, squamous cell cancer, lupus erythematosis, psoriasis, syphilis in various stages, or ringworm. Benzoapyrene bp and other polycyclic aromatic hydrocarbons pah are ubiquitous environmental pollutants and are suspected to be carcinogenic in man. Since that time new data have become available, which have been. Neither the european commission nor any person acting on behalf of the commission. This structure is also available as a 2d mol file or as a computed 3d sd file. Learn how californias climate is changing and how these changes are affecting the state. The in vivo formation of bp metabolitedna adducts has been characterized in a variety of target.
Material safety data sheet toxin and toxintarget database. Pyrene is a parent class of polycyclic aromatic hydrocarbons containing four fused rings. Once benzo apyrene has entered the small intestine, it is solubilized by bile salts and absorbed ermala et al. At the june 1992 crave work group meeting, a revised risk estimate for benzo apyrene was verified see additional comments for oral exposure.
Benzo apyrene in urban environments of eastern moscow. Polycyclic aromatic hydrocarbons pahs european commission. Relevant identified uses of the substance or mixture and uses advised against identified uses laboratory reagent. Sample application of adafs for the estimation of benzo apyrene cancer risk. Benzoapyrene is a polycyclic aromatic hydrocarbon and the result of incomplete combustion of organic matter at temperatures between 300 c 572 f and 600 c 1,112 f. All mass spectra in this site plus many more are available from the nistepanih mass spectral library. Pdf benzo alpha pyrene bap is a prototype polycyclic aromatic hydrocarbon pah. Here, we show that exposure of human cells to benzo apyrene 9,10diol7,8epoxide bpde, the active metabolite of benzo apyrene bap, which represents a most important carcinogen formed during food preparation at high temperature, smoking and by incomplete combustion processes, causes a prompt and sustained upregulation of the dna repair. Information from its description page there is shown below.
Benzoapyrene was also reported in cooking oils, butter, fats, margarine, coffee, tea, and some cereals, fruits and vegetables. Benzoapyrene bap is the most potent carcinogenic substance among the pahs, and as long as its relative contribution to total pah is relatively constant in foods, bap concentration is a good indicator of the total carcinogenic potency of a pah mixture alexander et al. However, the exact mechanisms underlying bapinduced. They are not produced or used commercially but are very commonly found since they are formed as a result of incomplete combustion. Substance name benzog,h, iperylene casrn 191242 last revised 12011990. Benzoapyrene c20h12 cid 2336 structure, chemical names, physical and chemical properties. Information on benzo apyrene bap, an indicator species for polycyclic aromatic hydrocarbons pahs, for use in responding to chemical incidents. This structure is also available as a 2d mol file or as a computed 3d sd file the 3d structure may be viewed using java or. Concentrations of benzo apyrene in benzo apyrene benzo apyrene was considered by previous iarc working groups in 1972, 1983, and 2005 iarc, 1973, 1983, 2010.
Pdf a multimedia transport model was used to evaluate the environmental partitioning of benzoapyrene bap. The florida department of environmental protection is the states lead agency for environmental management and stewardship protecting our air, water and land. Benzoapyrene undergoes photooxidation after irradiation in indoor sunlight or by fluorescent light in organic solvents. Polycyclic aromatic hydrocarbons benzoapyrene toxicological. Benzo apyrene is found in nature from the eruption of volcanoes and forest fires. Benzo apyrene page 3 of toxicological overview introduction pahs are a large group of compounds consisting of hydrocarbons containing two or more benzene rings fused together or to other hydrocarbon rings. Benzo apyrene is on the priority pollutant list published by the u. Benzoapyrene equivalents calculator multiple samples. Pollution levels and critical loads article pdf available in atmospheric chemistry and physics 173.
Pyrene is a colorless solid, solid and solutions have a slight blue fluorescence. Benzoapyrene is part of a class of chemicals called polycyclic aromatic hydrocarbons. Jul 01, 2014 information on benzo apyrene bap, an indicator species for polycyclic aromatic hydrocarbons pahs, for use in responding to chemical incidents. Where can benzoapyrene be found and how is it used. Adaptive upregulation of dna repair genes following benzoa. Iris file for information on longterm toxic effects other than carcinogenicity. They have a relatively low solubility in water, but are highly lipophilic. Like most pahs, benzo g,h,iperylene is used to make dyes, plastics, pesticides, explosives and drugs. Benzo apyrene standard benzo apyrene standard with a purity of 99. Instructions for benzo apyrene mcl notice tier 2 violation since exceeding the benzo apyrene maximum contaminant level mcl is a tier 2 violation, you must provide public notice to persons served as soon as practical but within 30 days after you learn of the violation 40 cfr 141.
It has also been used to make bile acids, cholesterol and steroids. Incidence of nonneoplastic and neoplastic lesions in female b6c3f 1 mice fed benzo apyrene in the diet for up to 2 years d53 table d. Benzoapyrene is found in nature from the eruption of volcanoes and forest fires. They are formed during the combustion of carbonaceous material at high temperatures 1. Benzoapyrene is an important commercial chemical used to make dyes. Please see the following for information about the library and its accompanying search program. Oxidized by ozone, chromic acid and chlorinating agents. Incompatible with strong oxidizing agents including various electrophiles, peroxides, nitrogen oxides and sulfur oxides. Benzoapyrene is on the priority pollutant list published by the u. Pdf benzo a pyrene at human blood equivalent level. Tobacco smoke contains high concentrations of pahs iarc, 2010. Benzo a pyrene at human blood equivalent level induces human lung epithelial cell invasion and migration via aryl hydrocarbon receptor signaling. Gcmsms analysis of benzoapyrene with agilent 7890 and.380 1160 1108 273 590 312 127 1300 1517 843 957 518 1268 575 334 142 458 1270 842 187 686 612 16 547 226 602 272 481 985